Get the SingleCare prescription discount card. Phenylephrine and pseudoephedrine are both adrenergic agonists and have some of the same side effects, though their difference in affinity for alpha- and beta-adrenergic receptors are responsible for some differences. Phenylephrine and pseudoephedrine are known to cause anxiety, dizziness, headache, insomnia, nervousness, and restlessness. In addition, pseudoephedrine has been documented to cause tachycardia, palpitations, arrhythmia, blurred vision, and anorexia.
It is difficult to define how frequently these side effects can occur. Patients with high blood pressure or other known cardiac conditions should not use pseudoephedrine without guidance from their physician. The following table is not intended to be a complete list of side effects. You should consult a pharmacist or other healthcare professional for a complete list. Source: DailyMed phenylephrine DailyMed pseudoephedrine. Phenylephrine and pseudoephedrine have a very similar drug interaction profile due to their adrenergic effects on the alpha and beta receptors.
Alpha-blockers, such as tamsulosin, may diminish the vasoconstrictive properties of both decongestants making them less effective. MAO inhibitors, such as selegiline, and ergot derivatives, such as bromocriptine, may enhance the hypertensive effects of the decongestants. This would be concerning in someone with pre-existing hypertension who may be considering decongestant use.
The combination of phenylephrine or pseudoephedrine with either MAO inhibitors or ergot derivatives is contraindicated. The following list is not meant to be a complete list of all potential drug interactions. Please consult your pharmacist or physician for a complete list and more information.
Phenylephrine and pseudoephedrine are available without a prescription and are generally considered to be safe drugs. Due to their effects on the cardiac system, patients with high blood pressure and heart disease should not use these drugs without explicit consent from their physician. These drugs are intended for short-term use for the relief of acute rhinitis and sinus pressure. Patients who experience these symptoms for longer than seven days, or who develop a fever, should consult a physician.
Phenylephrine is in pregnancy category C which means that studies in animals showed adverse effects to the fetus. When a drug is category C, there may be some situations where the benefit to the pregnant patient outweighs the risk, and phenylephrine should not be used without consent from your physician.
Pseudoephedrine is pregnancy category B which means that animal studies have not shown adverse effects to the fetus. Pseudoephedrine is considered safe to take when pregnant after consulting your physician. Pseudoephedrine should, however, be avoided in the first trimester. Phenylephrine is an over-the-counter nasal decongestant available in 5 mg and 10 mg tablets, as well as an oral solution. It is also available in an injectable form which is only used in an inpatient setting by medical professionals for low blood pressure.
Pseudoephedrine is an over-the-counter nasal decongestant available in 30 mg and 60 mg tablets, as well as mg and mg extended-release tablets. It is also available as an oral solution. Pseudoephedrine purchases must be done at a pharmacy and the purchase information must be logged into a database. Purchase limits are set by state and federal guidelines. Phenylephrine and pseudoephedrine are both adrenergic agonists.
Phenylephrine has primarily an affinity to only alpha-adrenergic receptors, while pseudoephedrine has an affinity to both alpha- and beta-adrenergic receptors. This is especially important if you will be giving cough and cold medications to a child. Nonprescription cough and cold combination products, including products that contain phenylephrine, can cause serious side effects or death in young children.
Do not give these products to children younger than 4 years of age. If you give these products to children 4 to 11 years of age, use caution and follow the package directions carefully. If you are giving phenylephrine or a combination product that contains phenylephrine to a child, read the package label carefully to be sure that it is the right product for a child of that age. Do not give phenylephrine products that are made for adults to children.
Before you give a phenylephrine product to a child, check the package label to find out how much medication the child should receive. Give the dose that matches the child's age on the chart. Ask the child's doctor if you don't know how much medication to give the child. If you are taking the liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication. If your symptoms do not get better within 7 days or if you have a fever, stop taking phenylephrine and call your doctor.
If you are taking the dissolving strips, place one strip on your tongue and allow it to dissolve. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
This medication is usually taken as needed. If your doctor has told you to take phenylephrine regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Phenylephrine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
Keep the cap on the bottle when not in use. To use the nasal drops , lie on your back with your head tilted back. Insert the correct number of drops and remain lying in this position for several minutes. Gently turn your head from side to side. Call your doctor if your symptoms do not improve after 3 days of treatment, or if you have a fever with a headache, cough, or skin rash. If you need surgery, tell the surgeon ahead of time that you are using phenylephrine nasal.
You may need to stop using the medicine for a short time. Since phenylephrine nasal is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. Ask a doctor or pharmacist before using any other cold, cough, or allergy medicine.
Many combination medicines contain pseudoephedrine. Taking certain products together can cause you to get too much of this medicine. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products.
Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide. Ask a doctor or pharmacist if it is safe for you to use phenylephrine nasal if you are also using any of the following drugs:. This list is not complete. Other drugs may interact with phenylephrine nasal, including prescription and over-the-counter medicines, vitamins, and herbal products.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or recommend therapy.
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